您现在的位置:首页 > >

Fluvastatin_sodium_DataSheet_MedChemExpress


Inhibitors, Agonists, Screening Libraries
www.MedChemExpress.com

Data Sheet
Product Name: Cat. No.: CAS No.: Molecular Formula: Molecular Weight: Target: Pathway: Solubility: Fluvastatin?(sodium) HY-14664A 93957-55-2 C24H25FNNaO4 433.45 HMG–CoA Reductase (HMGCR); Autophagy Metabolic Enzyme/Protease; Autophagy 10 mM in DMSO

BIOLOGICAL ACTIVITY: ?
Fluvastatin sodium is a competitive inhibitor of hydroxymethylglutaryl–coenzyme A reductase (HMGCR), used to treat hypercholesterolemia and to prevent cardiovascular disease. Target: HMGCR Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl–coenzyme A reductase (HMGCR), the enzyme that catalyzes the conversion of HMG–CoA to mevalonic acid, the rate–limiting step in cholesterol biosynthesis. Human hepatocellular carcinoma cell (HCC) studies indicate that Fluvastatin induces G2/M phase arrest. In the presence of Fluvastatin, HCC cells show a decrease of Bcl–2 and procaspase–9 expression, and an increase in Bax, cleaved caspase–3, and cytochrome c. Fluvastatin is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. ?

References:
[1]. Araújo FA, Rocha MA, Capettini LS, et al. 3–Hydroxy–3–methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS. 2012 24. [Epub ahead of print] [2]. Makabe S, Takahashi Y, Watanabe H, et al. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2–dependent antioxidant pathway. Atherosclerosis. 2010 Dec;213(2):377–84. [3]. Zhang W, Wu J, Zhou L, et al. Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells through mitochondria–operated pathway. Indian J Exp Biol. 2010 Dec;48(12):1167–74. [4]. Scripture CD, Pieper JA. Clinical pharmacokinetics of fluvastatin. Clin Pharmacokinet. 2001;40(4):263–81.

Caution: Product has not been fully validated for medical applications. For research use only.
Tel: 609-228-6898 ? ? Fax: 609-228-5909 ? ? E-mail: tech@MedChemExpress.com Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA

www.MedChemExpress.com



热文推荐
友情链接: 大学学习资料 人文社科 经营营销资料 工程资料大全 IT文档 自然科学